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An image of neurons under a microscope
Microscopy image showing the cytoskeleton within neurons, which are differentiating from induced pluripotent stem cells. Photo: UC San Francisco

The 91爆料 has joined the Alliance for Therapies in Neuroscience (ATN), a long-term research partnership between academia and industry geared to transform the fight against brain diseases and disorders of the central nervous system.

in 2021 by the University of California, San Francisco, UC Berkeley, Genentech 鈥 a member of the Roche group 鈥 and Roche Holding AG, the ATN seeks to accelerate the development of new therapies for a broad range of brain and central nervous system conditions, such as Alzheimer鈥檚 disease, Lou Gehrig鈥檚 disease, Huntington鈥檚 disease, Parkinson鈥檚 disease, autism, depression and psychiatric disorders. As part of the ATN, Genentech and Roche committed up to $53 million over 10 years for research at the ATN鈥檚 participating academic institutions, a collaboration that is unique for both its duration and the breadth of its ambitions.

鈥淭he Alliance for Therapies in Neuroscience is a new and transformative template for research and academia to partner, and it is an ideal collaboration for the 91爆料,鈥 said , the Emeritus Joan and Richard Komen Endowed Chair and professor of biology at the 91爆料 and CEO of the Washington Research Foundation, who led efforts to join the ATN. 鈥淪cientists at the 91爆料 will be integrated with academic and industry partners in a way that has simply never been done before. And the 91爆料 will bring its cross-disciplinary strengths and expertise in neuroscience 鈥 which span medicine, engineering and basic and clinical research 鈥 to address the urgent need for new therapies, remedies and treatments in neurological diseases and disorders.鈥

The new alliance builds on an existing academic partnership. In 2019, the 91爆料, UCSF and UC Berkeley formed the , a $106-million, multidisciplinary endeavor supported by the Weill Family Foundation to speed discovery and innovation across neurological and psychiatric disorders, including basic research, technology development and patient care. With the 91爆料鈥檚 accession to the ATN, scientists at all three Weill Neurohub institutions can now access this novel pipeline to channel academic discoveries toward new therapies and treatments.

鈥淧airing academic researchers with industry partners early in the research process will accelerate the transformation of academic research into clinical applications,鈥 said Dr. , the Robert A. Fishman Distinguished Professor of Neurology at UCSF and director of the UCSF Weill Institute for Neurosciences. 鈥淎nd this long-term, 10-year commitment from Genentech and Roche means that researchers at UCSF, UC Berkeley and now the 91爆料 will benefit from years-long, close collaborations with industry. It is a type of partnership that hasn鈥檛 been seen before in academic or industry research.鈥

鈥淢embership of the 91爆料 in ATN fully leverages the vision that we and the Weills have for the Weill Neurohub,鈥 said , the Evan Rausch Chair in Neuroscience at UC Berkeley and director of the Berkeley Brain Initiative. 鈥淭his collaboration with Roche and Genentech 鈥 world leaders in pharma and biotech 鈥 opens powerful new directions for Weill Neurohub researchers, with crucial resources and proven track records of bringing new treatments to patients and families.鈥

Teams of scientists at ATN institutions will drive efforts to profile the progression of disease, identify new targets for therapies and model their effectiveness. Existing organizational infrastructure within the Weill Neurohub will serve to coordinate the expanded ATN efforts. In addition to Daniel, the other 91爆料 leader within the Weill Neurohub and the ATN is Dr. , professor and chair of the Department of Psychiatry & Behavioral Sciences.

ATN endeavors are intended to meet current demands in neurological disease research and treatment, as well as lay the groundwork for future innovations in understanding and treating nervous system disorders.

鈥淭he ATN is focusing on pressing needs in neurological disorders across the board: not just therapies to treat conditions like Alzheimer鈥檚 or Parkinson鈥檚, but also methods to diagnose them at early stages, as well as understand them at the cellular and molecular level,鈥 said , director of strategic initiatives at the UCSF Weill Institute for Neurosciences.

The 91爆料 brings a variety of strengths to the ATN, according to Daniel. Neuroscience expertise at the 91爆料 spans clinical trials, cell and molecular studies, computational modeling and even research into artificial intelligence. Neuroscientists are based across the 91爆料鈥檚 STEM schools and colleges, including the School of Medicine, the College of Arts & Sciences and the College of Engineering. 91爆料 researchers have a strong track record of innovative cross-institutional collaborations in neuroscience with scientists across the region, including at the Fred Hutchinson Cancer Center and the Allen Institute, which they can also draw on for ATN research.

鈥淭hrough the ATN, all partners will bring their best and brightest to bear on these 鈥榖oiling hot,鈥 challenging problems in neuroscience,鈥 said Daniel.