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Does legal marijuana tempt pot users to consume more alcohol 鈥 or are they likely to opt for cannabis instead of chardonnay?

A 91爆料 team of researchers sought to address those questions in the context of evolving marijuana policies in the United States. Their , published online Dec. 21 in the journal Alcoholism: Clinical & Experimental Research, highlight the difficulties of gauging the impact of a formerly illicit drug as it moves into the mainstream.

Photo: Alex Ranaldi / Flickr

Recreational marijuana use is now legal in four states and medical marijuana in 23 states. Research on legalization policies has focused largely on how they impact marijuana access and use. But the 91爆料 team wanted to know how legalization affects the use of alcohol, by far the nation鈥檚 drug.

The majority of adults in the U.S. imbibe to varying degrees, and alcohol abuse is the third leading preventable cause of death nationwide. Drinking accounts for almost one-third of driving fatalities annually, and excessive alcohol use cost in 2006 alone.

鈥淲e chose to focus on alcohol because even relatively small changes in alcohol consumption could have profound implications for public health, safety and related costs,鈥 said lead author , a researcher in the 91爆料鈥檚 .

The researchers sought to determine whether legalizing marijuana led to it becoming a substitute for alcohol or tended to increase consumption of both substances. If it was the former, they reasoned, that could greatly reduce the costs of healthcare, traffic accidents and lower workplace productivity related to excessive drinking.

But if legalized marijuana resulted in increased use of both drugs, costs to society could increase dramatically, particularly since those who use both substances tend to use them . Those who use both substances simultaneously are twice as likely to drive drunk and face social troubles such as drunken brawls and relationship problems, a recent found.

Drawing on previous studies, the researchers hypothesized that legalization of marijuana could result in either substitution or complementary effects. Marijuana and alcohol both provide users with similar 鈥渞eward and sedation鈥 effects, the researchers noted, which could prompt users to substitute one for the other. But blood levels of THC, the chemical responsible for most of marijuana鈥檚 pleasurable psychological effects, increase with simultaneous alcohol use 鈥 so the quest for a better high might lead people to use both substances.

The researchers reviewed more than 750 studies on marijuana and alcohol use and focused on 15 that specifically addressed the links between marijuana policies and drinking. They looked at how decriminalized marijuana, medical marijuana and recreational marijuana impacted alcohol use.

The findings of those studies fluctuated widely, depending on the demographic and the type and frequency of alcohol and marijuana use. One study, for example, found that states where marijuana is decriminalized had more emergency room visits related to marijuana and fewer visits linked to alcohol and other drugs. Some studies found that high school seniors in states where pot was decriminalized tended to drink less, while other research found that college students who used pot also drank more.

Findings around medical marijuana also varied. One study reported that states with medical marijuana dispensaries had higher rates of both marijuana and alcohol use, as well as higher admissions into alcohol treatment facilities. But while states with medical marijuana had fewer alcohol-related fatalities overall, those with dispensaries saw more of those deaths.

Other research found that while legalized medical marijuana wasn鈥檛 associated with any increases in underage drinking, it was linked with more binge drinking and simultaneous use of pot and alcohol among adults.

The issue is particularly complicated in Washington state, which legalized recreational marijuana use in 2012 after privatizing liquor sales the previous year. As a result, the uptick in alcohol sales made it difficult to isolate the impacts of legalized marijuana on drinking from the change in alcohol policy.

The researchers concluded that there鈥檚 evidence of marijuana and alcohol being both substitutes and complements. Given the rapidly evolving landscape of marijuana policy, they say further study will be important to understand how changes in marijuana laws impact the use of alcohol and other drugs.

In particular, Guttmannov谩 said, future studies should address specific dimensions of marijuana policies, timing of policy change and implementation, and different aspects of marijuana and alcohol use, such as age of users and whether they are episodic or regular consumers.

鈥淭his is a complicated issue and requires a nuanced approach,鈥 she said. 鈥淲e were hoping to have more clear-cut answers at the end of our research. But you know what? This is the science of human behavior, and it鈥檚 messy, and that鈥檚 OK.鈥

Co-authors at the 91爆料 Center for the Study of Health and Risk Behaviors are Associate Director , professor of psychiatry , assistant professor of psychiatry , and research assistant professor . Other co-authors are 91爆料 School of Social Work lecturer and investigator and Social Development Research Group investigator .

The research was funded by the National Institute on Alcohol Abuse and Alcoholism and the National Institute on Drug Abuse.