{"id":68309,"date":"2026-05-29T09:57:14","date_gmt":"2026-05-29T16:57:14","guid":{"rendered":"https:\/\/www.washington.edu\/research\/?page_id=68309"},"modified":"2026-05-29T10:12:11","modified_gmt":"2026-05-29T17:12:11","slug":"renew-or-close-multi-institutional-study","status":"publish","type":"page","link":"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/","title":{"rendered":"Renew or Close Approved Multi-institutional Study"},"content":{"rendered":"<p><img decoding=\"async\" class=\"WP-PrintIcon\" src=\"https:\/\/www.washington.edu\/research\/wp-content\/plugins\/wp-print\/images\/printer_famfamfam.gif\"  alt=\"Print\" title=\"Print\" style=\"border: 2px;\">&nbsp;<a href=\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/print\/\" title=\"Print\" rel=\"nofollow\" target=\"_blank\">Print<\/a><\/p>\n<div class=\"table-of-contents\">\n<h2 id=\"toc\">Table of Contents<\/h2>\n<ul class=\"list-unstyled\">\n<li><a href=\"#1\">Before You Begin<\/a>\n<ul>\n<li><a href=\"#1a\">How does continuing review and closure work for multi-site studies?<\/a><\/li>\n<li><a href=\"#1b\">What if I only need to close one site in a multi-site study?<\/a><\/li>\n<\/ul>\n<\/li>\n<li><a href=\"#2\">Steps for Submitting Multi-site Continuing Review or Closure<\/a><\/li>\n<li><a href=\"#3\">What to Expect After Submitting Multi-site Continuing Review or Closure<\/a><\/li>\n<li><a href=\"#4\">Steps for Submitting Site Closure<\/a><\/li>\n<li><a href=\"#5\">After Site Closure<\/a><\/li>\n<\/ul>\n<\/div>\n<h2 id=\"1\">Before You Begin<\/h2>\n<div class=\"accordion \" id=\"accordion\">\n<div class=\"screen-reader-text\"><\/div>\n<div class=\"card\" id=\"1a\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">How does continuing review and closure work for multi-site studies?<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<p><strong>Continuing review is conducted at the study level only<\/strong>. Information about any institutions relying on the 91爆料 for review must be included in the overall study continuing review.<\/p>\n<p><strong>Site and study approvals share the same end date<\/strong>. The approval end date for each site is the same as the approval end date for the study overall.<\/p>\n<p><strong>One report is used for renewal and closure<\/strong>. The continuing review report supports both study renewal and study closure and includes:<\/p>\n<ul>\n<li>The Continuing Review SmartForm in Zipline<\/li>\n<li>A <a href=\"\/research\/forms-and-templates\/application-status-report-renew-or-close\/\">Status Report form<\/a> uploaded to the SmartForm<\/li>\n<\/ul>\n<p><strong>Closure is triggered by milestones<\/strong>. On the Continuing Review SmartForm, when you indicate that the first four research milestones have been met for the entire study, Zipline prompts you to acknowledge study closure.<\/p>\n<p>For more information:<\/p>\n<ul>\n<li><a href=\"\/research\/hsd\/irb-reliances\/single-irb\/uw-irb-as-a-single-irb\/steps-in-the-single-irb-review-process-follow-ons\/#cr\">Multi-site continuing review process<\/a><\/li>\n<li><a href=\"\/research\/hsd\/irb-reliances\/single-irb\/uw-irb-as-a-single-irb\/steps-in-the-single-irb-review-process-follow-ons\/#closure\">Site or study closure process<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"card\" id=\"1b\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">What if I only need to close one site in a multi-site study?<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<p>If the involvement of a relying institution has ended, you may submit a <strong>site closure<\/strong>, rather than closing the entire study.<\/p>\n<ul>\n<li><strong>Site closures are optional<\/strong>. HSD does not require relying sites to be closed in Zipline when site activities stop. You may choose to close a site when the activities of the relying institution\u2019s employees or agents are <strong>no longer considered human subjects research<\/strong>.<\/li>\n<li>A site closure closes the SITE record in Zipline while keeping the parent STUDY record open.<\/li>\n<li>Site closure is submitted through a study modification that updates the approved Multi-site or Collaborative Research Supplement to remove the site.<\/li>\n<li>Once the modification is approved, HSD staff will close the SITE record.<\/li>\n<li><strong>No site closure letter is issued.<\/strong><\/li>\n<\/ul>\n<p>To close the entire study, use the <a href=\"#2\">Multi-site Continuing Review or Closure process<\/a>.<\/p>\n<p>For more information:<\/p>\n<ul>\n<li><a href=\"\/research\/hsd\/irb-reliances\/single-irb\/uw-irb-as-a-single-irb\/steps-in-the-single-irb-review-process-follow-ons\/#closure\">Site or study closure process<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<h2 id=\"2\">Steps for Submitting Multi-site Continuing Review or Closure<\/h2>\n<div class=\"accordion \" id=\"accordion\">\n<div class=\"screen-reader-text\"><\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Step 1: Create the Continuing Review in Zipline<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<ul>\n<li>Click <strong>Renew or Close<\/strong> in the study workspace\n<ul>\n<li>The study must be Approved, Lapsed, or Suspended for this action to be available.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37225 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-Renew-or-Close-1.png\" alt=\"screenshot of the renew or close button in the study workspace\" width=\"1024\" height=\"387\" \/><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Indicate that the purpose of the submission is continuing review and click <strong>Continue <\/strong><\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37224 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-CR-purpose.png\" alt=\"screenshot of the submission purpose showing continuing review selected\" width=\"1024\" height=\"441\" srcset=\"https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-CR-purpose.png 1162w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-CR-purpose-300x129.png 300w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-CR-purpose-1024x441.png 1024w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-CR-purpose-768x330.png 768w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-CR-purpose-375x161.png 375w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-CR-purpose-750x323.png 750w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-CR-purpose-1140x491.png 1140w\" sizes=\"auto, 100vw\" \/><\/p>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Step 2: Complete the Continuing Review\/Study Closure Page<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<ul>\n<li><strong>Your responses should include information for all participating sites.<\/strong><\/li>\n<li>In Continuing Review Information #3 (Study wide enrollment totals) on the Continuing Review SmartForm, enter the total number of participants enrolled across all sites.<\/li>\n<li>You may ignore the system message showing: \u201c<em>Confirmed sites: X of X. Total enrollment for pSites with completed reports<\/em>\u201d<\/li>\n<li>If you select the first four research milestones, Zipline will prompt you to acknowledge that the study will be closed.<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37240 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-study-closure.png\" alt=\"screenshot of a continuing review indicating study closure\" width=\"1024\" height=\"274\" srcset=\"https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-study-closure.png 1129w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-study-closure-300x80.png 300w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-study-closure-1024x274.png 1024w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-study-closure-768x205.png 768w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-study-closure-375x100.png 375w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-study-closure-750x201.png 750w\" sizes=\"auto, 100vw\" \/><\/p>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Step 3: Complete and upload the Status Report form<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<p>The <a href=\"\/research\/forms-and-templates\/application-status-report-renew-or-close\/\">Status Report<\/a> should describe<strong> study progress across all participating institutions<\/strong>, not just the 91爆料 site. If your study requires radiation safety approval at 91爆料, attach the radiation safety renewal here as well.<\/p>\n<ul>\n<li>Click the link to open the Status Report template<\/li>\n<li>Complete the template and save it to your computer<\/li>\n<li>Attach the template to the SmartForm, either using drag and drop, or by clicking <strong>Add<\/strong><\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37242 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-upload-CR.png\" alt=\"screenshot of the continuing review attachment\" width=\"1024\" height=\"224\" srcset=\"https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-upload-CR.png 1166w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-upload-CR-300x66.png 300w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-upload-CR-1024x224.png 1024w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-upload-CR-768x168.png 768w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-upload-CR-375x82.png 375w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-upload-CR-750x164.png 750w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-upload-CR-1140x249.png 1140w\" sizes=\"auto, 100vw\" \/><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Click <strong>Save <\/strong>and<strong> Exit <\/strong>to leave the SmartForm and return to the submission workspace<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Step 4: PI or PI proxy must submit<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<ul>\n<li>Click Submit and complete required verifications<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37241 size-medium\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-submit-CR.png\" alt=\"screenshot of the the submit button\" width=\"262\" height=\"300\" srcset=\"https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-submit-CR.png 277w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-submit-CR-262x300.png 262w\" sizes=\"auto, (max-width: 262px) 100vw, 262px\" \/><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<h2 id=\"3\">What to Expect After Submitting Multi-site Continuing Review or Closure<\/h2>\n<p>The continuing review transitions to Pre-Review state and is now in HSD\u2019s queue for review.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37223 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-CR-in-Pre-Review.png\" alt=\"screenshot of the continuing review workspace in Pre-Review\" width=\"1024\" height=\"288\" \/><\/p>\n<p>After the IRB has reviewed the application, the PI, any PI proxies, and primary contact will receive a notification that:<\/p>\n<ul>\n<li>The IRB has approved the renewal or closure; OR<\/li>\n<li>The IRB requires more information or a change before approving the renewal or closure<\/li>\n<\/ul>\n<p>Review <a href=\"\/research\/hsd\/training\/zipline-online-help-library\/respond-to-hsd\/\">Respond to HSD<\/a> for more information on submitting responses.<\/p>\n<h3>After Continuing Review Approval<\/h3>\n<p>Once the continuing review is approved:<\/p>\n<ul>\n<li>The parent study record is updated.<\/li>\n<li>For closure requests, the parent study and all participating sites are closed.<\/li>\n<li>For renewal requests, the new expiration date is applied to the parent study and all participating sites.<\/li>\n<li>The PI, PI proxy, and primary contact receive a notification with the Continuing Review or Closure approval letter.<\/li>\n<\/ul>\n<h2 id=\"4\">Steps for Submitting Site Closure<\/h2>\n<p>If only one relying institution is ending participation, you may request a site closure. This is done through a study modification that updates the Multi-site or Collaborative Research Supplement to remove the site.<\/p>\n<div class=\"accordion \" id=\"accordion\">\n<div class=\"screen-reader-text\"><\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Step 1: Locate and update the currently approved Multi-site or Collaborative Research Supplement<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<ul>\n<li>In the parent study for the site, locate and download the currently approved SUPPLEMENT Multi-site or Collaborative Research in the Documents tab<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37228 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-find-supplement-2.png\" alt=\"screenshot of the study workspace showing the multi-site supplement in the documents tab\" width=\"1024\" height=\"350\" \/><\/p>\n<ul>\n<li>Update the SUPPLEMENT Multi-site or Collaborative Research to remove the information for the site that you wish to close<\/li>\n<li>Save the revised SUPPLEMENT to your computer<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Step 2: Create a study modification in Zipline<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<ul>\n<li>In the parent study for the site, click Modify Study to initiate a study modification<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37231 size-medium\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-modify-study.png\" alt=\"screenshot of the modify study button\" width=\"241\" height=\"300\" srcset=\"https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-modify-study.png 322w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-modify-study-241x300.png 241w\" sizes=\"auto, (max-width: 241px) 100vw, 241px\" \/><\/p>\n<ul>\n<li>Indicate that the purpose of the submission is a modification\/update and the modification scope is \u201cOther parts of the study\u201d and click Continue<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37229 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-scope.png\" alt=\"screenshot of the modification scope\" width=\"1024\" height=\"421\" srcset=\"https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-scope.png 1307w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-scope-300x123.png 300w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-scope-1024x421.png 1024w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-scope-768x316.png 768w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-scope-375x154.png 375w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-scope-750x308.png 750w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-scope-1140x468.png 1140w\" sizes=\"auto, 100vw\" \/><\/p>\n<ul>\n<li>On the Modification Summary page, indicate that the involvement of a relying institution has ended and the site should be closed, and click Continue<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37230 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-summary.png\" alt=\"screenshot of the modification summary\" width=\"1024\" height=\"492\" srcset=\"https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-summary.png 1618w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-summary-300x144.png 300w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-summary-1024x492.png 1024w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-summary-768x369.png 768w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-summary-1536x739.png 1536w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-summary-375x180.png 375w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-summary-750x361.png 750w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-mod-summary-1140x548.png 1140w\" sizes=\"auto, 100vw\" \/><\/p>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Step 3: Update the Zipline study to remove information about the site<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<ul>\n<li>In the Zipline application, use the left hand navigator to go to the Study Related Documents page and locate the SUPPLEMENT Multi-site and Collaborative Research<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37233 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-update-supplement.png\" alt=\"screenshot of updating the multi-site supplement\" width=\"1024\" height=\"366\" srcset=\"https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-update-supplement.png 1876w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-update-supplement-300x107.png 300w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-update-supplement-1024x366.png 1024w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-update-supplement-768x274.png 768w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-update-supplement-1536x549.png 1536w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-update-supplement-375x134.png 375w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-update-supplement-750x268.png 750w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-update-supplement-1140x407.png 1140w\" sizes=\"auto, 100vw\" \/><\/p>\n<ul>\n<li>Click UPDATE next to the SUPPLEMENT, select the revised version from your computer, and click OK<\/li>\n<li>If desired, you can make additional changes to your study application<\/li>\n<li>Save and exit the SmartForm<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Step 4: PI or PI proxy must submit study modification<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<ul>\n<li>In the modification workspace, click Submit to send the modification requesting site closure to HSD<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37232 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-submit-mod.png\" alt=\"screenshot of the submit button\" width=\"1024\" height=\"377\" srcset=\"https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-submit-mod.png 1740w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-submit-mod-300x110.png 300w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-submit-mod-1024x377.png 1024w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-submit-mod-768x282.png 768w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-submit-mod-1536x565.png 1536w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-submit-mod-375x138.png 375w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-submit-mod-750x276.png 750w, https:\/\/www.washington.edu\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-site-closure-submit-mod-1140x419.png 1140w\" sizes=\"auto, 100vw\" \/><\/p>\n<h2><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<h2 id=\"5\">After Site Closure<\/h2>\n<p>Once HSD has approved the modification updating the SUPPLEMENT Multi-site and Collaborative Research, HSD staff will close the SITE record in Zipline. <strong>No site closure letter is issued. <\/strong><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-37227 size-large\" src=\"\/research\/wp-content\/uploads\/Managing-Multi-site-Studies-Closed-Site.png\" alt=\"screenshot of a closed site\" width=\"1024\" height=\"196\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Table of Contents Before You Begin How does continuing review and closure work for multi-site studies? What if I only need to close one site in&#8230;<\/p>\n","protected":false},"author":15,"featured_media":0,"parent":11143,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-builder-units-small-hero.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-68309","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Renew or Close Approved Multi-institutional Study - 91爆料 Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Renew or Close Approved Multi-institutional Study - 91爆料 Research\" \/>\n<meta property=\"og:description\" content=\"Table of Contents Before You Begin How does continuing review and closure work for multi-site studies? What if I only need to close one site in...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/\" \/>\n<meta property=\"og:site_name\" content=\"91爆料 Research\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-29T17:12:11+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/\",\"url\":\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/\",\"name\":\"Renew or Close Approved Multi-institutional Study - 91爆料 Research\",\"isPartOf\":{\"@id\":\"https:\/\/www.washington.edu\/research\/#website\"},\"datePublished\":\"2026-05-29T16:57:14+00:00\",\"dateModified\":\"2026-05-29T17:12:11+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.washington.edu\/research\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Human Subjects Division\",\"item\":\"https:\/\/www.washington.edu\/research\/hsd\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Learn the Process\",\"item\":\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Renew or Close Approved Multi-institutional Study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.washington.edu\/research\/#website\",\"url\":\"https:\/\/www.washington.edu\/research\/\",\"name\":\"91爆料 Research\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.washington.edu\/research\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Renew or Close Approved Multi-institutional Study - 91爆料 Research","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/","og_locale":"en_US","og_type":"article","og_title":"Renew or Close Approved Multi-institutional Study - 91爆料 Research","og_description":"Table of Contents Before You Begin How does continuing review and closure work for multi-site studies? What if I only need to close one site in...","og_url":"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/","og_site_name":"91爆料 Research","article_modified_time":"2026-05-29T17:12:11+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/","url":"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/","name":"Renew or Close Approved Multi-institutional Study - 91爆料 Research","isPartOf":{"@id":"https:\/\/www.washington.edu\/research\/#website"},"datePublished":"2026-05-29T16:57:14+00:00","dateModified":"2026-05-29T17:12:11+00:00","breadcrumb":{"@id":"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/renew-or-close-multi-institutional-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.washington.edu\/research\/"},{"@type":"ListItem","position":2,"name":"Human Subjects Division","item":"https:\/\/www.washington.edu\/research\/hsd\/"},{"@type":"ListItem","position":3,"name":"Learn the Process","item":"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/"},{"@type":"ListItem","position":4,"name":"Renew or Close Approved Multi-institutional Study"}]},{"@type":"WebSite","@id":"https:\/\/www.washington.edu\/research\/#website","url":"https:\/\/www.washington.edu\/research\/","name":"91爆料 Research","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.washington.edu\/research\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.washington.edu\/research\/wp-json\/wp\/v2\/pages\/68309","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.washington.edu\/research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.washington.edu\/research\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.washington.edu\/research\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.washington.edu\/research\/wp-json\/wp\/v2\/comments?post=68309"}],"version-history":[{"count":1,"href":"https:\/\/www.washington.edu\/research\/wp-json\/wp\/v2\/pages\/68309\/revisions"}],"predecessor-version":[{"id":68310,"href":"https:\/\/www.washington.edu\/research\/wp-json\/wp\/v2\/pages\/68309\/revisions\/68310"}],"up":[{"embeddable":true,"href":"https:\/\/www.washington.edu\/research\/wp-json\/wp\/v2\/pages\/11143"}],"wp:attachment":[{"href":"https:\/\/www.washington.edu\/research\/wp-json\/wp\/v2\/media?parent=68309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}